In 1998, Toxic Audio launched its quirky show in an abandoned storefront at the Orlando International Fringe Festival. To their amazement, people began cramming into that storefront to see them. The show caught the attention of Disney executives who hired them as featured performers at the Disney/MGM Studios. Soon after, the group was crowned champion at the National Harmony Sweepstakes in California.

In the year 2003, Toxic Audio's album, Chemistry was named "Album of the Year" by the Contemporary Acappella Society of America. The group has made national TV appearances with Ed McMahon and Wayne Brady, and even got to sing a reggae-style weather report on ESPN2's morning show "Cold Pizza". Toxic Audio won the 2004 Drama Desk Award for “Unique Theatrical Experience” for their Off-Broadway Show in New York’s John Houseman Theatre where they continue to electrify audiences by exploring the boundaries of the human voice.

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